Human choline dehydrogenase: Medical promises and biochemical challenges

F Salvi, G Gadda - Archives of biochemistry and biophysics, 2013 - Elsevier
… characterization of the enzyme has lagged behind due to difficulties in the obtainment of …
the medical relevance and the physiological roles of human CHD, highlights the biochemical

Applications of deep eutectic solvents in biotechnology and bioengineering—Promises and challenges

YP Mbous, M Hayyan, A Hayyan, WF Wong… - Biotechnology …, 2017 - Elsevier
biological sectors. To date, the applications of DESs have shown great promise, especially
in the medical … is available about ILs, the toxicity of choline-based mixtures hardly could be …

[HTML][HTML] Challenges in metabolomics-based tests, biomarkers revealed by metabolomic analysis, and the promise of the application of metabolomics in precision …

A Di Minno, M Gelzo, M Caterino, M Costanzo… - International Journal of …, 2022 - mdpi.com
… to be used in precision medicine and precision prevention approaches. The use of big
biobanks and electronic medical records that integrate biological information with clinical data …

[HTML][HTML] CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression

Y Li, X Shen, X Yang, F Lian, Y Li, J Li, Y Huang… - Frontiers in …, 2023 - frontiersin.org
… In recent years, the role of CHDH in medicine has … the difficulties in purifying CHDH,
biochemists lost interest in the enzyme and little is known about the biochemical properties of human

Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition

YQ Goh, G Cheam, Y Wang - Journal of Agricultural and Food …, 2021 - ACS Publications
… for many age-related health problems, there is a pressing need to … via mitochondrial enzyme
choline dehydrogenase, (60) and … , citicoline is a medicine containing CDP-choline that was …

The glycine betaine role in neurodegenerative, cardiovascular, hepatic, and renal diseases: Insights into disease and dysfunction networks

JA Rosas-Rodríguez, EM Valenzuela-Soto - Life sciences, 2021 - Elsevier
… , agriculture, and clinical medical studies due to its chemical and … synthesis: the choline
dehydrogenase and betaine aldehyde … with the progression of health problems, most of the GB …

[图书][B] Lehninger principles of biochemistry

DL Nelson, AL Lehninger, MM Cox - 2008 - books.google.com
… knockout mice, with enormous promise for advances in basic biochemistry, physiology, and
… that relate biochemistry to medicine and to health issues in general. Some of the medical

[HTML][HTML] Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation

T McClatchie, M Meredith, MO Ouédraogo… - Journal of Biological …, 2017 - ASBMB
… Because betaine can be synthesized in mammalian cells via choline dehydrogenase (…
Isolated maturing oocytes autonomously synthesized betaine in vitro in the presence of choline, …

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

KM Brindle, SE Bohndiek, FA Gallagher… - … in medicine, 2011 - Wiley Online Library
promise for the imaging of cancer in preclinical work, both for diagnosis and for monitoring
therapy response. If the challenges in translating this technique to human … the biochemical

Osmotic Contribution of Synthesized Betaine by Choline Dehydrogenase Using In Vivo and In Vitro Models of Post-traumatic Syringomyelia

DD Pukale, D Lazarenko, SR Aryal, F Khabaz… - Cellular and Molecular …, 2023 - Springer
… and its synthesis enzyme choline dehydrogenase (CHDH) … known osmoprotectant role
in biological systems, along with … options to overcome challenges associated with clinical …