Identification of a unique inhibitor-binding site on choline kinase α

SL Kall, EJ Delikatny, A Lavie - Biochemistry, 2018 - ACS Publications
… I clinical trials and show promise as a cancer treatment. To … pyruvate kinase/lactate
dehydrogenase coupled system. The … enzyme and did not resolve solubility issues (see Figure …

Understanding and Preventing Disease-Associated Anaerobic Choline Metabolism by the Human Gut Microbiota

S Bodea - 2016 - dash.harvard.edu
… for me, and despite all the challenges, I will forever cherish all … -gut microbe interactions
holds the promise of revealing new … have been set by the Institute of Medicine at 425 mg/day for …

Applications of deep eutectic solvents in biotechnology and bioengineering—Promises and challenges

YP Mbous, M Hayyan, A Hayyan, WF Wong… - Biotechnology …, 2017 - Elsevier
biological sectors. To date, the applications of DESs have shown great promise, especially
in the medical … is available about ILs, the toxicity of choline-based mixtures hardly could be …

Challenges in metabolomics-based tests, biomarkers revealed by metabolomic analysis, and the promise of the application of metabolomics in precision medicine

A Di Minno, M Gelzo, M Caterino, M Costanzo… - International Journal of …, 2022 - mdpi.com
… to be used in precision medicine and precision prevention approaches. The use of big
biobanks and electronic medical records that integrate biological information with clinical data …

Succinic semialdehyde dehydrogenase: biochemical–molecular–clinical disease mechanisms, redox regulation, and functional significance

KJ Kim, PL Pearl, K Jensen, OC Snead… - Antioxidants & redox …, 2011 - liebertpub.com
… More fully described later in this review, SSADH deficiency leads to protean CNS findings,
and remains a disease that is challenging to identify based solely upon clinical examination. …

[图书][B] Biochemistry for medical professionals

T Komoda, T Matsunaga - 2015 - books.google.com
… few ethical problems as it does not require destruction of the living embryo. It promises to be
… The isozyme of human lactate dehydrogenase (LDH; EC 1.1.1.27) is a tetramer that consists …

Regulated extracellular choline acetyltransferase activity—the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathway

S Vijayaraghavan, A Karami, S Aeinehband… - PloS one, 2013 - journals.plos.org
… PLOS ONE promises fair, rigorous peer review, broad scope, … be indicative of the
biological equilibrium system to maintain … This may also be due to other difficulties commonly …

A new trend on biosensor for neurotransmitter choline/acetylcholine—an overview

A Khan, AAP Khan, AM Asiri, MA Rub, N Azum… - Applied biochemistry …, 2013 - Springer
… This review tries to address issues on ways to minimise the … tools whose range of applications
in medical diagnostics [11], … this methodology holds great promise for broad applications in …

Accumulation of Betaine in the Developing Mouse Oocyte Requires Choline Dehydrogenase

T McCLATCHIE - 2018 - ruor.uottawa.ca
… Here I explore the enzyme choline dehydrogenase (CHDH; EC 1.199.1) as a method by …
of choline. Chdh-/- oocytes failed to produce betaine when similarly cultured in choline. This …

[图书][B] For the love of enzymes: The odyssey of a biochemist

A Kornberg - 1991 - books.google.com
… record of my circuitous journey from medicine to biochemistry and the intricacies of how we
… Whither human nutrition? How can we cope with the numerous and complex problems and …