Intrinsic factors behind long COVID: IV. Hypothetical roles of the SARSCoV2 nucleocapsid protein and its liquid–liquid phase separation

A Eltayeb, F Al‐Sarraj, M Alharbi… - Journal of Cellular …, 2024 - Wiley Online Library
… This review highlights basic studies of the nucleocapsid protein and its ability to undergo …
this ability of the nucleocapsid protein for phase separation may contribute to long COVID. This …

The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …

W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
… Among the four structural proteins and sixteen nonstructural … COVID-19 [20, 24, 25]. Therefore,
this paper focuses on the … domain (CTD) and three intrinsically disordered regions (IDRs), …

Overview of the SARS-CoV-2 nucleocapsid protein

A Eltayeb, F Al-Sarraj, M Alharbi, R Albiheyri… - International Journal of …, 2024 - Elsevier
four structural proteins are prospective coronavirus therapy … of the intrinsic disorder
predisposition of the SARS-CoV-2 N … by phosphorylation of a hypothetical NLS, piggybacking …

Diversity of short linear interaction motifs in SARS-CoV-2 nucleocapsid protein

P Schuck, H Zhao - MBio, 2023 - Am Soc Microbiol
… 3–10 amino acid long binding motifs in intrinsically disordered … 2 to 4, the color and size of
the circles are scaled from large … The analysis of hypothetical sequence space was carried out …

The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis

R McBride, BC Fielding - Viruses, 2012 - mdpi.com
coronavirus proteins, such as the replicase proteins (ORFs 1a and 1b) and the four major
structural proteins: nucleocapsid … and is a 44 amino-acid long integral membrane protein that is …

SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns

N Shukla, A Prasad, U Kanga… - Physiological …, 2021 - journals.physiology.org
… The RNA genome of the virus is bound to the nucleocapsid (… that of mitochondrial NADH
dehydrogenase subunits 4 and 5 (… hypothetical ORFs containing domains of unknown function (…

Are the Comorbidities Constitute an Intrinsic Factor for Long COVID?

R Ashmawy, EA Hammouda, YA El-Maradny… - 2024 - preprints.org
… Almost 60% of long COVID symptoms present at week 4 fully … a role in the development
and persistence of long COVID … Persistent fatigue following SARSCoV-2 infection is common …

Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development

A Gruca, J Ziemska-Legiecka, P Jarnot, E Sarnowska… - BMC …, 2021 - Springer
… angiotensin-converting enzyme 2 (ACE2) receptor [3, 4]. The … of spike, nsp3 and nucleocapsid
proteins should not be … motifs that are often parts of intrinsically disordered regions (IDRs). …

Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection

C Diemer, M Schneider, J Seebach, J Quaas… - Journal of molecular …, 2008 - Elsevier
… , SARS-CoV was shown to belong to the novel group IV,4, 5 … , we show that SARS-CoV N
induces the intrinsic apoptotic … Hypothetical model for correlation of nuclear localization and …

Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid

H Zhao, AM Syed, MM Khalid, A Nguyen… - Nucleic Acids …, 2024 - academic.oup.com
… are linked and flanked by large intrinsically disordered regions (IDRs) … Schematic organization
of N-protein and hypothetical … (iv) We identify a second site for stem–loop RNA binding on …