… % in the levels of DNA Ligase III and DNA Ligase IV fails to produce … DNA DSBs either by
B-NHEJ or by D-NHEJ. Knock down in cell lines with hypomorphic mutations in DNA Ligase IV, …

… ligase III) is often implicated. To test the requirement for LIGIII in A-NHEJ we constructed
a … functional relevance since even low levels of LIGIII are sufficient for effective A-NHEJ [65]. …

… that if DNA ligase IV acts exclusively within the D‐NHEJ, … The adequate fitting achieved
in both types of cells with the … Since DNA ligase IV, unlike DNA ligases III and I, is present …

… result in as little as a three-fold reduction in enzymatic activity. … , and autolysis precluded
adequate post-mortem histological … overall NHEJ efficiency is markedly reduced, and the DNA …

… NHEJ components (Ku, DNA‐PKcs, Xrcc4 and DNA ligase IV… in DNA ligase IV retained
sufficient DNA ligase IV activity to … We also observed lower levels of DNA ligase IV in 180BR …

… - mainly the orthologs of KU, DNA ligase IV (LIG4) as well as … We opt for the term DNA-PKcs-dependent
(D-NHEJ) for this … cells suggesting that the reduced level of nuclear LIG3 has in …

… polymerase μ and λ to add nucleotides; and the DNA ligase IV … The reported values are
averages of three independent … Artemis, DNA-PK cs , and X4·LIV were not sufficient for NHEJ of …

… the role of NHEJ-DNA-DSB-repair, DNA-ligase IV, and DNA-PK in … Induction of DNA
damage was strongly reduced after … NHEJ is involved in surviving topoisomerase II-mediated …

… have an unidentified DNA ligase that catalyses NHEJ, the … ::TRP1), the rate of colony
formation decreased in the parent, hdf1 … for (this work) nor sufficient to complement Cdc9-mediated …

… an NHEJ component and suggest that a significant defect in … residual DNA ligase IV
activity in 180BR cells is sufficient for V… The affinity-purified protein from three transcription/translation …