MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist
C Cialdai, M Tramontana, R Patacchini, A Lecci… - European journal of …, 2006 - Elsevier
… results indicate that MEN15596 is a potent and selective nonpeptide tachykinin NK 2 receptor
antagonist which possesses a good oral bioavailability. This feature renders MEN15596 a …
antagonist which possesses a good oral bioavailability. This feature renders MEN15596 a …
The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics
V Schelfhout, V Van De Velde… - Therapeutic …, 2009 - journals.sagepub.com
… the nonpeptide tachykinin NK2 receptor antagonist SR48968 (… a bicyclic peptide tachykinin
NK2 receptor antagonist. The aim … , MEN15596, a new orally active tachykinin NK2 receptor …
NK2 receptor antagonist. The aim … , MEN15596, a new orally active tachykinin NK2 receptor …
Discovery of a New Series of Potent and Selective Linear Tachykinin NK2 Receptor Antagonists
V Fedi, M Altamura, RM Catalioto… - Journal of medicinal …, 2007 - ACS Publications
… The product 48f (MEN15596), bearing a methyl substituent on the … different tachykinin
NK 2 receptor antagonists are presently undergoing advanced clinical studies, the non-peptide …
NK 2 receptor antagonists are presently undergoing advanced clinical studies, the non-peptide …
Antagonist profile of ibodutant at the tachykinin NK2 receptor in guinea pig isolated bronchi
P Santicioli, S Meini, S Giuliani, A Lecci… - European journal of …, 2013 - Elsevier
… profile of the non-peptide tachykinin NK 2 receptor antagonist ibodutant (MEN15596) in
guinea pig isolated main bronchi contractility. The antagonist potency of ibodutant was …
guinea pig isolated main bronchi contractility. The antagonist potency of ibodutant was …
Tachykinin NK2 receptor antagonists. A patent review (2006–2010)
M Altamura - Expert Opinion on Therapeutic Patents, 2012 - Taylor & Francis
… is still no tachykinin NK2 receptor antagonist approved for use in … role of tachykinin NK2
receptor antagonists in human therapy. … hexapeptide nepadutant and the nonpeptide ibodutant. …
receptor antagonists in human therapy. … hexapeptide nepadutant and the nonpeptide ibodutant. …
Characterization of ibodutant at NK2 receptor in human colon
P Santicioli, S Meini, S Giuliani, C Catalani… - European journal of …, 2013 - Elsevier
… profile of the nonpeptide tachykinin NK 2 receptor antagonist ibodutant (MEN15596) through
… characterization of the tachykinin NK 2 receptor antagonist ibodutant (MEN15596) is …
… characterization of the tachykinin NK 2 receptor antagonist ibodutant (MEN15596) is …
The place of tachykinin NK2 receptor antagonists in the treatment diarrhea-predominant irritable bowel syndrome
A Szymaszkiewicz, A Malkiewicz… - … of Physiology and …, 2019 - publicum.umed.lodz.pl
… two selective NK2 receptor antagonists: nepadutant (MEN11420) and ibodutant (MEN15596) …
This novel non-peptide molecule was designed for the treatment of IBS-D by Menarini (57-…
This novel non-peptide molecule was designed for the treatment of IBS-D by Menarini (57-…
… ([1-(2-Phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl}-ethylcarbamoyl)-cyclopentyl]-amide) at the Human Tachykinin NK2 Receptor
S Meini, F Bellucci, C Catalani, P Cucchi… - … of Pharmacology and …, 2009 - ASPET
… Ibodutant (MEN15596, [1-(2-phenyl-1R-{[1-(tetrahydropyran-4-… Tachykinin NK 2 receptor
antagonists presently in clinical … the nonpeptide antagonist ibodutant with the human tachykinin …
antagonists presently in clinical … the nonpeptide antagonist ibodutant with the human tachykinin …
[PDF][PDF] Ibodutant Treatment of Irritable Bowel Syndrome
NK Tachykinin - Drugs of the Future, 2008 - researchgate.net
… Ibodutant (MEN-15596) is a potent and selective tachykinin NK2 receptor antagonist with a
… as compared to the nonpeptide NK2 receptor antagonist saredutant, although maintaining …
… as compared to the nonpeptide NK2 receptor antagonist saredutant, although maintaining …