… procaspase-3 fused with ODD 548–603 and HIV-Tat protein-transduction domain (PTD). The
final product was named TOP3 (Tat-ODD-Procaspase-3) [… type-1 Tat protein and efficiently …

… and hypoxia-specific strategies, are summarized in Table 1. … we chose an endogenous
cytotoxic protein, procaspase-3, which is … HIF-1α targeted for VHL-mediated destruction by proline …

… Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated
protein destruction motif of HIF-1α containing Pro564. FEBS Letter. 580: 5718–5722. …

… of the fusion protein into cells and delivery of the fusion protein to … The procaspase-3 domain
is an inactive proenzyme form of … PTD–ODD–procaspase-3 has been shown to specifically …

… We have previously reported that procaspase-3 fused with a von … The ODD domain contains
a VHL-mediated protein … The stability of TOP3 is regulated by the same mechanism as HIF-…

… reported that fusion with a VHL-mediated protein destruction … has to enter cells to undergo
the ODD regulatory mechanism… an endogenous cytotoxic protein procaspase-3, which is a …

… , hypoxia-activated prodrugs, hypoxia-specific gene therapy, and hypoxia-targeting fusion
… Procaspase-3 can be used as a cytotoxic domain of fusion protein. For overcoming the …

… To evaluate the efficacy of PTDODD fusion protein as a hypoxia-specific probe, we …
Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein …

… We developed and validated a fusion protein, TAT-ODD-procaspase-3 (TOP3), to …
Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein …

… of the mechanism in the PTD-mediated internalization [57]. … the Tat–ODD fusion protein with
cytotoxicity shows a hypoxia-… with the resultant fusion protein, Tat–ODD–procaspase-3 (TOP3…