Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

RJ Reiter, R Sharma, F Simko… - Cellular and Molecular …, 2022 - Springer
Melatonin’s ability to arrest SARS-CoV-2 infections may reduce health care exhaustion by
melatonin that support its use in the prevention and/or treatment of SARS-CoV-2 infections. …

[HTML][HTML] Protective effect of melatonin administration against SARS-CoV-2 infection: A systematic review

A Molina-Carballo, R Palacios-López… - Current Issues in …, 2022 - mdpi.com
… to carry out a systematic review of its possible role in the treatment and/or prevention of COVID…
This paper also highlights that the mechanism of action of melatonin may help explain the …

[HTML][HTML] COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor

EL Feitosa, FTDSS Júnior, JADON Neto… - … journal of medical …, 2020 - ncbi.nlm.nih.gov
potential of this complex Mpro-melatonin (ligand highlighted in yellow). Relationship between
the infectious condition and the therapeutic potential … that the infection by SARS-CoV-2 is …

In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression …

L Artigas, M Coma, P Matos-Filipe, J Aguirre-Plans… - PLoS …, 2020 - journals.plos.org
… and melatonin against the infection of SARS-CoV-2. We have also predicted a potential
therapeutic effect of … Our analysis has highlighted pirfenidone as one of the best candidates for …

[HTML][HTML] Melatonin use for SARSCoV2 infection: Time to diversify the treatment portfolio

RJ Reiter, R Sharma, DX Tan, RL Neel… - Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Melatonin intervenes at several levels to reduce the severity of an infection mediated by
SARSCoV2… of the therapeutic potential of melatonin as a SARSCoV2 main protease inhibitor…

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

E Cecon, D Fernandois, N Renault, CFF Coelho… - Cellular and Molecular …, 2022 - Springer
SARS-CoV-2-infected K18-hACE2 mice. Here, we show that treatment of K18-hACE2 mice
with melatonin … first clinical results highlight a therapeutic potential of melatonin in COVID-19. …

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

KB Juybari, MH Pourhanifeh, A Hosseinzadeh… - Virus research, 2020 - Elsevier
melatonin therapy for viral infections with focus on possible … of melatonin may highlight this
hypothesis that melatonin may … dysfunction following SARS-CoV-2 infection may influence …

[HTML][HTML] Assessing the therapeutic potential of agomelatine, ramelteon, and melatonin against SARS-CoV-2

PK Yadalam, TM Balaji, S Varadarajan… - Saudi Journal of …, 2022 - Elsevier
… if infection from SARS-CoV-2 could be treated by melatonin … are being investigated as
potential modalities against the … the present study highlight the antiviral role of melatonin-related …

Possible application of melatonin in long COVID

DP Cardinali, GM Brown, SR Pandi-Perumal - Biomolecules, 2022 - mdpi.com
Melatonin may be particularly effective at reducing the signs and symptoms of SARS-CoV-2
infection due to its … Overall, the findings highlight the need to optimize options other than …

The coronavirus disease 2019 (COVID-19): key emphasis on melatonin safety and therapeutic efficacy

E Ramos, F Lopez-Munoz, E Gil-Martin, J Egea… - Antioxidants, 2021 - mdpi.com
… taking melatonin had a reduced risk of SARS-CoV-2 infectionmelatonin described to date,
we must highlight its antioxidant… pleiotropic melatonin endow it with an extraordinary potential