… Patients and methods We randomized 10 patients with sepsis to receive meropenem by
intermittent bolus administration (n = 5; 1 g 8 hourly) or an equal dose administered by …

… The results of the current study suggest that continuous administration of meropenem does
not improve clinically relevant outcomes in critically ill patients with sepsis, including long-…

… the total doses of meropenem used between treatment groups. Since all renal dose adjustments
… , the difference in degree of renal impairment should not have substantially affected our …

… optimal regimens are given to critically ill patients in our hospital, … meropenem derived from
patients within the ICU and to use this model to select dosing regimens for critically ill patients …

… meropenem dosing regimens and patient renal function due to its observational nature,
which may have limited the generalisability of the results. However, it reported real-life data, …

… therapy to evaluate illness severity and organ dysfunction. Laboratory parameters included
… for renal function assessment, and tracking total fluid infusion during the first 24 hours of …

… , from intermittent to continuous … renal function is necessary for choosing the correct dose
of antimicrobial drugs, especially in critically ill patients in whom the occurrence of acute renal …

… of renal function, a daily dose of 8000 mg of meropenem was required for intermittent … the
largest pharmacokinetic study of meropenem in critically ill patients to date. This sample size …

… degrees of renal failure are often seen in critically ill patients in ICU. These patients may
be … , although there are no clinical studies showing it is superior over intermittent infusion [6]. …

… It is possible that increasing the dosage to 6 g/day in renal function normal patients can
achieve … [22] observed the pharmacokinetics of meropenem in critically ill patients receiving …