… the modification of CEA with CRT and TAT PTD could enhance … of both CRT and TAT PTD
induced more potent anti-tumor immune responses than the single use of CRT or TAT PTD. …

… To enhance the immunogenecity of CEA, we developed a fusion gene (CRT-TAT-ΔCEA) of
the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid of …

… Second, modification of CEA antigens with HIV Tat, one of the well-… vaccination of DCs
loaded with bacteria-derived Tat-CEA induced potent CTL-mediated anti-CEA immune responses …

… of carcinoembryonic antigen (CEA) mRNA [3]. Since then, … dramatically augmented by
structural modifications of the 5′ … lymph nodes to induce potent immune responses, intradermal, …

… of both the cellular and humoral immune responses is … presentation to induce potent and
broad immune responses. Studies … Enhanced induction of anti-tumor immunity in human and …

… However, in other settings the potency of immune responses induced … Modification of CEA
with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC …

… vaccination (DCNLGPCEA) elicits mitogen induced and CEA … In this approach, CEA was
delivered to the immune system … by DCs into induction of anti-tumor immunity having two unique …

… induction of anti-tumor immune responses, especially CTL … modified 708 antibody was able
to induce a strong immune … DCs expressing CEA and SVV in the presence of CAR-TAT led to …

… immune response to tumor associated CEA without inducing … a Tat-CEA fusion protein also
led to preventative anti-tumor … -mediated responses compared to non-modified CEA plasmid …

… a personalized mRNA vaccine for induction of immune responses. … Modification of CEA
with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC …