… In this study, we confirmed a higher mutation frequency and a distinct mutational profiling
in CRCs with MSI. NGS assays may be designed to detect driver mutations for targeted …

… Conclusions: This study shows that BRAF mutations profiled from stage II and III colon
cancer tumors were associated with poor SAR and validates and explains, at least in part, …

… mutation profiling and microsatellite instability (MSI) status were associated with
clinicopathological features and the prognosis in metastatic colorectal cancer (mCRC), mutations in …

… colorectal cancers (CRC) display MSI owing either to epigenetic silencing of MLH1 or a
germline mutation … Strikingly, BRAF mutations in colorectal tumors are more frequent in sporadic …

… microsatellite instability (MSI). MSI is typical of hereditary … colorectal cancer that accounts
for 2% to 3% of all colorectal … sporadic colorectal carcinomas in which constitutional mutations …

… colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with
thousands of small mutations—the microsatellite instability (MSI… subtype of colorectal cancers. …

… comprehensive characterization of the genomes of 224 cancerous colorectal tumors and
normal pairs [1•… Mutation profiling and microsatellite instability in stage II and III colon cancer: an …

… mutations of genes associated with dysregulated KRAS signaling were noted in the G1
subgroup. Overall, the mutation spectra and microsatellite … LS CRC mutational profile is similar to …

… of unknown significance and MSI-high cases were identified in eight cases (8/67, 11%),
and two of these colorectal cancers had multiple POLE mutations, showing an ultramutated …

… MSI, and microsatellite stable (MSS) tumors. Lynch syndrome… of all colorectal cancers, is
caused by a germ line mutation in … profiling by microarrays in a group of colorectal cancers …