NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required …

H Zhou, J Wang, P Zhu, H Zhu, S Toan, S Hu… - … research in cardiology, 2018 - Springer
… apoptosis and provoked microvascular dysfunction. In summary, our data illustrated that
NR4A1 serves as a novel culprit factor in cardiac microvascular IR injury that operates through

NR4A1 promotes oxidative stresses after myocardial ischemia reperfusion injury in aged mice

X Peng, W Wang, W Wang, J Qi - Experimental Gerontology, 2022 - Elsevier
NR4A1 is increased following cardiac microvascular IR injury… In contrast, NR4A1 deletion
preserved cellular energy, suppressed … Similarly, we observed NR4A1 deficiency suppressed

NR4A1 Aggravates Myocardial IschaemiaReperfusion Injury by Inhibiting OPA1-Mediated Mitochondrial Fusion

M Li, Y Hu, H Zhou, Y Chen - Journal of cardiovascular translational …, 2023 - Springer
… In addition, we verified the effect of NR4A1 expression on cell activity by using NR4A1-…
oxidative stress via AMPK/NR4A1 suppression can prevent diabetic cardiomyopathy by …

[HTML][HTML] Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function

ZX Liu, X Han, Y You, GJ Xin, LM Li, JM Gao… - Journal of …, 2024 - Elsevier
ischemia perfusion, which in turn aggravate cardiac injury … effect of SSNX on cardiac
microvascular I/R injury. Our results … cardiac microvascular I/R injury by inhibiting the NR4A1/Mff/…

NR4A1 knockdown confers hepatoprotection against ischaemiareperfusion injury by suppressing TGFβ1 via inhibition of CYR61/NF‐κB in mouse hepatocytes

J Cao, T Xu, C Zhou, S Wang, B Jiang… - Journal of Cellular …, 2021 - Wiley Online Library
… 4, group A, member 1 (NR4A1) can aggravate ischaemia-reperfusion (I/R) injury in the … of
NR4A1 contributes to protection against cardiac microvascular I/R injury through inhibition of …

Dexmedetomidine alleviates pulmonary ischemia-reperfusion injury through modulating the miR-21-5p/Nr4a1 signaling pathway

W Dong, H Yang, M Cheng, X Zhang… - Acta Biochimica …, 2020 - abp.ptbioch.edu.pl
microvascular clip, resulting in pulmonary ischemia for 30 minutes. The microvascular clip
damage is aggravated and even irreversible damage occurs after blood flow restores in the …

NR4A1 silencing protects against renal ischemia-reperfusion injury through activation of the β-catenin signaling pathway in old mice

W Shi, J Dong, Y Liang, K Liu, Y Peng - Experimental and Molecular …, 2019 - Elsevier
… of NR4A1, leading to aggravated renal function damage, … cases, NR4A1 is up-regulated in
cardiac microvascular IRI, … Inhibition of NR4A1 suppresses the apoptosis of renal cells in old …

NR4A1 promotes cerebral ischemia reperfusion injury by repressing Mfn2-mediated mitophagy and inactivating the MAPK–ERK–CREB signaling pathway

Z Zhang, J Yu - Neurochemical Research, 2018 - Springer
cardiac IR injury, increased NR4A1 disrupts protective mitophagy, evoking cardiomyocyte
death via … questioned whether NR4A1 is also involved in cerebral IR injury via modification of …

The role and regulatory mechanism of HIF-1α in myocardial injury in rats undergoing cardiopulmonary bypass

M Zhang, N Zhou, F Cao, W Liu, H Yuan… - Acta …, 2023 - Taylor & Francis
… CPB-induced myocardial ischaemia-reperfusion injuryNR4A1 aggravates ischaemia-induced
cardiomyocyte apoptosis in patients with metabolic syndrome, and suppression of NR4A1

Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials

J Wang, S Toan, H Zhou - Pharmacological Research, 2020 - Elsevier
NR4A1 in mitophagy activation are completely different. Mitophagy is activated by DUSP1
[113] through … and inhibited by NR4A1 [107] through suppression of FUN14 domain containing …