… that natural products provide valuable leads in the discovery of potent, chemically diverse,
non-peptidic inhibitors … of natural, non-peptidic inhibitors of ubiquitin-proteasome pathway has …

… in isolating inhibitors against the proteasome and E1 enzyme from marine natural resources.
In this review, we summarize the structures and biological activities of natural products that …

… The ubiquitin-proteasome system, discovered more than thirty years ago, is the main …
Synthetic non peptidic compounds have not yet reached the expected inhibitory activities. However, …

… ubiquitin–proteasome … inhibitors and inhibitors of ubiquitinating/deubiquitinating enzymes.
With the feature of unique structure and bioactivity, secondary metabolites (natural products) …

… ubiquitinproteasome pathway. In addition, this review covers the chemistry of synthetic and
natural proteasome inhibitors, … for the design of non-peptidic PGPH or TL specific inhibitors. …

… of peptidic inhibitors is that they can be degraded in living organisms by endogenous
proteases. This explains the interest in non-peptidic, naturally occurring, proteasome inhibitors, as …

… inhibitors proved to be powerful tools for investigating many important cellular processes
regulated by the ubiquitin-proteasome … The first natural non– peptidic proteasome inhibitor …

… The major pathway for systematic degradation of intracellular proteins is the ubiquitin–proteasome
system, 1 which is involved in many physiologically important cellular processes, …

… lactacystin was the first natural non-peptidic proteasome inhibitor [19]… inhibitors have
been instrumental to our fundamental understanding and appreciation of the ubiquitin–proteasome …

… ubiquitin–proteasome pathway and inhibitors targeting this pathway, including proteasome
inhibitors, … Class C: Lactacystin ( Figure 2 ), the first natural non-peptidic proteasome inhibitor, …