Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism

HK Wong, PO Bauer, M Kurosawa… - Human molecular …, 2008 - academic.oup.com
effects in models of HD, first we focused on their effect on htt-… Another interesting discovery
in this study is that UPS activity … that survived after 14 weeks and seizure-free; water, n = 8; tg-…

The case for sequencing the genome of the electric eel Electrophorus electricus

JS Albert, HH Zakon, PK Stoddard… - Journal of Fish …, 2008 - Wiley Online Library
… electricus be accorded the highest priority for genomic … system with broad applications for
discovering principles in other … ’s disease, epilepsy, muscular dystrophy and cardiac arrhythmia…

Disease Models for Rare Genetic Disorders

S Kanakarajan, R Selvaraj, PK Kaleena - Rare Genetic Disorders …, 2024 - Springer
… is evident that the potential for discovery is vast. The synergy … to ethical guidelines and
prioritize animal welfare when … valuable models for diseases like muscular dystrophy, cancer, and …

31 DIAGNOSIS OF UNCERTAINTY TO POSITIVE IMPACT

J VEACH - Visions: The Inspirational Journeys of Epilepsy …, 2019 - books.google.com
… , muscular dystrophy, and Parkinson’s disease combined, … ’s annual Camp Discovery
for children with epilepsy aged 7 to … Leveraging technology has been a high priority for …

Mitochondrial quality control as a therapeutic target

HB Suliman, CA Piantadosi - Pharmacological reviews, 2016 - ASPET
… They participate in cell communication and regulation of inflammation and are important
considerations in aging, drug toxicity, and pathogenesis. The cell’s capacity to maintain its …

[HTML][HTML] CRISPR-Cas9 technology for the creation of biological avatars capable of modeling and treating pathologies: From discovery to the latest improvements

A Nasrallah, E Sulpice, F Kobaisi, X Gidrol, W Rachidi - Cells, 2022 - mdpi.com
… have oxidative reactions with water where DNA is engaged, … mutations in the Duchenne
muscular dystrophy (Dmd) gene [… are always the concern and the priority. CRISPR-Cas9 should …

[图书][B] Neuroscience: exploring the brain, enhanced edition: exploring the brain

M Bear, B Connors, MA Paradiso - 2020 - books.google.com
… A unique feature of our book is the Path of Discovery boxes, in … The quality of the art has
always been a high priority for the authors… Water diffusion in the brain occurs preferentially along …

The muscular atrophies and allied disorders

CD ARING, S Cobb - Medicine, 1935 - journals.lww.com
… Questions of priority we leave to the bibliophile and medical … Muscular atrophy may occur
in any condition affecting the … , absent ankle jerks and slight ataxia accompanied epilepsy. …

[PDF][PDF] Pignol et al.(43) Pub. Date: Jun. 11, 2009

PFR Lassauniere - researchgate.net
effect on the cells vis-a-vis cell death. [0027] In the case of the treatment of muscular dystrophy,
the invention … and Washed With 50 ml of Water and 50 ml of salt Water. After drying over …

[PDF][PDF] Unique challenges in the development of therapies for neurological disorders

G O'Neill - Clinical trials in Neurology: Design, Conduct …, 2012 - ndl.ethernet.edu.et
… is the translation of these discoveries from the laboratory … development should be a high
priority. For timely delivery of … termination codons in Duchenne muscular dystrophy and A β …