… wide range of bioactivities they may inhibit efflux pumps. The current work repurposed the
bioactive alkaloid roemerine as a potential efflux pump inhibitor. In Bacillus subtilis, both Bmr …

… the inhibition of efflux pumps by alkaloids without illuminating the precise mechanisms
involved. … As a crucial source of bioactive molecules, natural plants have great promise for the …

… most important sources of bioactive carbazole alkaloids [70,71… to further develop potent
inhibitors of these efflux pumps [73]. … Roemerine (Table 4) is an aporphine alkaloid isolated from …

… the activities of bioactive aporphine alkaloids: thaliporphine, … of actions by aporphine
alkaloids in metabolic syndrome. … Conjugation of roemerine to the substrate of efflux pump may …

… Aporphine alkaloids are a class of natural products which is … , an aporphine alkaloid, is
one of the prominent bioactive … 1), an aporphine alkaloid, is one of the prominent bioactive …

… Different bioactive alkaloids with different skeletons and … The low activity is commonly due
to the action of efflux pumps… Aporphine alkaloids are comprised of an aporphine nucleus, …

… of efflux pump inhibitors (EPIs) to interfere with efflux is one … the efflux of norfloxacin through
the NorA efflux pump protein in … of silibinin to inhibit the efflux pumps of Bacillus subtilis was …

… Different bioactive alkaloids with different skeletons and … in combination with efflux pump
inhibitors significantly increases … ., Repurposing bioactive aporphine alkaloids as efflux pump …

… of bioactive antimicrobial candidates’ discovery. This review aims to focus on terpenoid,
alkaloid, and … Most alkaloids act as efflux pump inhibitors (EPIs) to exert antimicrobial effects—for …

… Alkaloids are among the most biologically active plant … as berberines, aporphines and
benzylisoquinoline alkaloids. Most … with existing, potent efflux pump inhibitors could result in a …