… B(a)P-induced lung tumors. The aim of this study was to assess whether roflumilast alone or
… might have dose-dependent inhibition on lung carcinogenesis induced by carcinogen B(a)P …

… Second-generation PDE4 inhibitors (eg, cilomilast and roflumilast) have more … inhibits
lung carcinogenesis in response to B(a)P in A/J mice, and this effect results from inhibition of …

… These medicines have a strong potential to inhibit the disease development and progression,
including cancer [16]. The natural compounds or active compounds of the medicinal plants …

… treatment, the total proteins in the treated cells and the lung of mice were extracted using the
RIPA buffer containing a protease inhibitor … AB[a]P-induced lung cancer mouse model was …

… induced lung cancer signaling pathway could be inhibited by … the lipid peroxides to cause
lung cancer in Swiss albino mice.… attenuate the lung carcinogenesis by BaP-treatment in mice.[ …

… a week for four successive weeks to induce lung cancer in mice. The mice were treated with
MEBA at doses of 200 and 400mg/kg b.wt. The lung weight, body weight, lipid peroxidation, …

… In addition, roflumilast was reported to ameliorate bleomycin-induced lung fibrosis [46] and
also inhibited benzo (a) pyrene induced lung carcinogenesis in mice models [47]. Further, it …

… In mice with STK11 mutant tumors, Roflumilast treatment reduced the number of liver
metastases; however, a significant reduction was not achieved compared to that in the non-…

… As a component of your chemotherapy regimen, your physician may prescribe medications
that have the ability to eradicate cancer cells or inhibit their proliferation. Possible treatment …

… Roflumilast also improves bleomycin-induced lung fibrosis [27] and has been shown to
inhibit lung carcinogenesis induced by benzo (a) pyrene in mice models [28]. Several …