Rutin ameliorates hepatic fibrosis via targeting hepatic stellate cells' activation, proliferation and apoptosis

WH El-Maadawy, SH Seif el-Din, SM Ezzat… - Journal of Herbs …, 2021 - Taylor & Francis
… study investigates whether rutin is a promising candidate for treating hepatic fibrosis and
to … on hepatic stellate cell line (HSC-T6) whereas liver fibrosis was established in rats via

[PDF][PDF] Rutin Ameliorates Hepatic Fibrosis via Targeting Hepatic Stellate Cells' Activation, Proliferation and Apoptosis

M Safar - 2021 - buescholar.bue.edu.eg
rutin ameliorated the elevated serum levels of ALT and AST, denoting the property of rutin
in maintaining the integrity of the cell membrane of liver … , rutin inhibited the proliferation of …

[HTML][HTML] Rutin mitigates hepatic fibrogenesis and inflammation through targeting TLR4 and P2X7 receptor signaling pathway in vitro and in vivo

LS Hou, ZY Cui, P Sun, HQ Piao, X Han, J Song… - Journal of Functional …, 2020 - Elsevier
… HSC-T6, a rat hepatic stellate cell line, was cultured in DMEM with 10% FBS, 100 U/…
hepatocyte homeostasis. In our results, rutin ameliorated hepatic fibrosis and inflammation through

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

J Li, P Liu, R Zhang, L Cao, H Qian, J Liao, W Xu… - Journal of …, 2011 - Elsevier
cell death in activated hepatic stellate cells (HSCs) and ameliorating the development of liver
fibrosis … MATERIALS AND METHODS: : In vitro, icaritin-induced cell death rates in HSC-T6 (…

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways

Q Cheng, C Li, C Yang, Y Zhong, D Wu, L Shi… - Chemico-biological …, 2019 - Elsevier
… at least 24 h, processed by routine histology procedures, embedded in paraffin… ameliorated
hepatic fibrosis by inhibiting HSC activation and the excessive accumulation of ECM through

Fisetin alleviates thioacetamide-induced hepatic fibrosis in rats by inhibiting Wnt/β-catenin signaling pathway

AA El-Fadaly, NA Afifi, W El-Eraky… - …, 2022 - Taylor & Francis
through inhibition of hepatic stellate cells (HSCs) activation … reported that fisetin ameliorated
hepatic inflammation and … obtained by routine processing of the autopsy liver specimens of …

Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon …

L Zhang, H Zhang, J Gu, W Xu, N Yuan, J Sun… - International …, 2022 - Elsevier
… tissues were fixed in 4 % paraformaldehyde for a period of at least 24 h, processed by
routine … One study reported that glabridin could ameliorate liver injury mainly by suppressing …

Rutin attenuates hepatotoxicity in high‐cholesterol‐diet‐fed rats

SD AlSharari, SS Al-Rejaie… - … and Cellular …, 2016 - Wiley Online Library
… in hepatocyte apoptosis and liver fibrotic responses [19]. Engulfment of apoptotic bodies by
hepatic stellate cells … In the present study, Rutin supplement ameliorated the effect of HCD by …

Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells

Y Peng, H Yang, N Wang, Y Ouyang… - … and Liver …, 2014 - journals.physiology.org
… The liver functions were measured by routine methods used … In DMN-treated rats, AKF-PD
and PFD treatment ameliorated … better than PFD in AST and ALT amelioration (P < 0.05), there …

[HTML][HTML] Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways

J Hui, G Jiarong, W Yongzhong, Z Jiafu… - Journal of Traditional …, 2016 - Elsevier
… Carbon tetrachloride (CCl 4 )-treated rats and hepatic stellate cells (HSCs) were used. The
effect of PNS on CCl 4 -induced liver fibrosis was studied with histochemical and biochemical …