… of fifteen symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and
… better reactivator to obidoxime for NEMP (VX-surrogate)-inhibited BChE. The in vitro results …

… In summary, it is worth noting the similarities in the arrangement of reactivators in the
cholinesterase active sites for this step. In both AChE and BuChE, the constraint-forced position of …

… ACh) [1], and molecular modeling and simulation studies have … a reactivator to aged, or
phosphorylated, cholinesterase has … and unsymmetrical isoquinolinium-5-carbaldoximes showed …

… All novel reactivators were screened for their reactivation ability at a single concentration (10
µM) towards OP-inhibited hAChE after 10 min, as this concentration is considered …

… The reactivation of acetylcholinesterase (AChE) is critical in … human ChEs [(AChE and
butyrylcholinesterase (BChE)) from … dynamic (MD) simulations between five reactivators and the …

… The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic
function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via cleavage of …

… supported by molecular docking studies of K075 (Fig. 7b). The … They carried out the in-vitro
screening of these oximes firstly … of phosphylated human acetyl and butyrylcholinesterases. …

… (ACh)[1], and molecular modeling and simulation studies have … a reactivator to aged, or
phosphorylated, cholinesterase has … and unsymmetrical isoquinolinium-5-carbaldoximes showed …

… binding of cholinesterase (ChE) enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase
(… transmission can be restored by AChE reactivators or by enzyme synthesis de novo [ …

… Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as
acetylcholinesterase and butyrylcholinesterase reactivators. Journal of Enzyme Inhibition and …