Effects of diazoxide on Aβ1-42-induced expression of the NR2B subunit in cultured cholinergic neurons

J Zhu, Q Fu, C Xia, G Ma - Molecular Medicine Reports, 2015 - spandidos-publications.com
… of the amyloid-β (Aβ) peptide, a hyperphosphorylation of tau … may improve the learning ability
and memory of rat models of AD (22)… KATP channel openers as brain protective agents has …

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update

C Villa, H Suphesiz, R Combi, E Akyuz - Mechanisms of ageing and …, 2020 - Elsevier
… senile plaques constituted by the amyloid-β (Aβ) peptide and … inhibitor Dasatinib ameliorated
AD pathology by directly … K ATP channel activation with diazoxide leads to a memory

Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue

MJ Rodríguez Allué, M Martínez Moreno… - … Medicine and Cellular …, 2013 - diposit.ub.edu
… [127], and 3xTgAD mice treated with 10 mg/kg/day diazoxide … of the KATP channel opener
diazoxide ameliorates diseaseamyloid 𝛽peptide toxicity,” Brain Research, vol. 706, no. 2, pp. …

In Vivo Regulation of Amyloid-β by Glucose and Insulin in a Mouse Model of Alzheimer's Disease

M Stanley - 2017 - search.proquest.com
… Modulation of hippocampal KATP channels affects ISF Aβ … insulin to improve memory
is currently under investigation … investigated whether the KATP channel agonist, diazoxide, …

Crosstalk between Alzheimer's disease and diabetes: a focus on anti-diabetic drugs

G Goodarzi, SS Tehrani, SE Fana… - … Brain Disease, 2023 - Springer
… may interact with amyloid-β protein deposition and tau protein … Studies on a 3xTg-AD mouse
model fed a high-fat diet … pathway between Aβ and the K-ATP channel. For example, Aβ …

Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus

M Martínez-Moreno, M Batlle, FJ Ortega… - Neuroscience, 2016 - Elsevier
… administration of Dzx ameliorates disease progression and … on plasmalemma K ATP
channels, K ATP channel activity at … tau pathologies and improves memory in the 3xTgAD mouse

Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

D Liu, M Pitta, H Jiang, JH Lee, G Zhang, X Chen… - Neurobiology of …, 2013 - Elsevier
… Thus, nicotinamide suppresses AD pathology and cognitive decline in a mouse model of …
treatment ameliorates amyloid β-peptide (Aβ) and tau pathologies in the brains of 3xTgAD mice

L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner

Y Wang, MP Mattson - Neurobiology of aging, 2014 - Elsevier
… of amyloid β-peptide, and selective hyperphosphorylated tau … L-VGCC and NMDA receptor
activation in perturbed synaptic … tau pathologies in a mouse model of Alzheimer's disease

Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching

MP Mattson - International Review of Neurobiology, 2020 - Elsevier
… ’ of AD, namely amyloid β-peptide (Aβ) plaques and Tau tangles. … (eg, diazoxide and valproic
acid) to ameliorate cognitive … A study of old 3xTgAD mice (mice expressing mutant human …

Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway

N Watamura, N Kakiya, P Nilsson, S Tsubuki… - Molecular …, 2022 - nature.com
… in our AD mouse model. Our findings provide a mechanism … disease characterized by the
deposition of amyloid β peptide (… diazoxide (Dz), a well-known K ATP channel activator with a …