ATP-Sensitive potassium channel subunits in neuroinflammation: novel drug targets in neurodegenerative disorders
F Maqoud, R Scala, M Hoxha… - … Disorders-Drug …, 2022 - ingentaconnect.com
… KATP channels are involved in amyloid-β (Aβ)-induced … In animal models, subclinical
doses of a KATP blocker tolbutamide or a KATP opener diazoxide differentially restrained Aβ-…
doses of a KATP blocker tolbutamide or a KATP opener diazoxide differentially restrained Aβ-…
Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
MJ Rodríguez Allué, M Martínez Moreno… - … Medicine and Cellular …, 2013 - diposit.ub.edu
… [127], and 3xTgAD mice treated with 10 mg/kg/day diazoxide … of the KATP channel opener
diazoxide ameliorates disease … amyloid 𝛽peptide toxicity,” Brain Research, vol. 706, no. 2, pp. …
diazoxide ameliorates disease … amyloid 𝛽peptide toxicity,” Brain Research, vol. 706, no. 2, pp. …
Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update
… senile plaques constituted by the amyloid-β (Aβ) peptide and … inhibitor Dasatinib ameliorated
AD pathology by directly … K ATP channel activation with diazoxide leads to a memory …
AD pathology by directly … K ATP channel activation with diazoxide leads to a memory …
In Vivo Regulation of Amyloid-β by Glucose and Insulin in a Mouse Model of Alzheimer's Disease
M Stanley - 2017 - search.proquest.com
… Modulation of hippocampal KATP channels affects ISF Aβ … insulin to improve memory
is currently under investigation … investigated whether the KATP channel agonist, diazoxide, …
is currently under investigation … investigated whether the KATP channel agonist, diazoxide, …
Crosstalk between Alzheimer's disease and diabetes: A focus on anti-diabetic drugs
… may interact with amyloid-β protein deposition and tau protein … Studies on a 3xTg-AD mouse
model fed a high-fat diet … pathway between Aβ and the K-ATP channel. For example, Aβ …
model fed a high-fat diet … pathway between Aβ and the K-ATP channel. For example, Aβ …
Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus
M Martínez-Moreno, M Batlle, FJ Ortega… - Neuroscience, 2016 - Elsevier
… ameliorates disease progression and causes neuroprotection in animal models of Alzheimer’s
disease … action of Dzx on plasmalemma K ATP channels, K ATP channel activity at the cell …
disease … action of Dzx on plasmalemma K ATP channels, K ATP channel activity at the cell …
Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
… Thus, nicotinamide suppresses AD pathology and cognitive decline in a mouse model of …
treatment ameliorates amyloid β-peptide (Aβ) and tau pathologies in the brains of 3xTgAD mice…
treatment ameliorates amyloid β-peptide (Aβ) and tau pathologies in the brains of 3xTgAD mice…
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner
Y Wang, MP Mattson - Neurobiology of aging, 2014 - Elsevier
… of amyloid β-peptide, and selective hyperphosphorylated tau … L-VGCC and NMDA receptor
activation in perturbed synaptic … tau pathologies in a mouse model of Alzheimer's disease …
activation in perturbed synaptic … tau pathologies in a mouse model of Alzheimer's disease …
Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching
MP Mattson - International Review of Neurobiology, 2020 - Elsevier
… ’ of AD, namely amyloid β-peptide (Aβ) plaques and Tau tangles. … (eg, diazoxide and valproic
acid) to ameliorate cognitive … A study of old 3xTgAD mice (mice expressing mutant human …
acid) to ameliorate cognitive … A study of old 3xTgAD mice (mice expressing mutant human …
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway
N Watamura, N Kakiya, P Nilsson, S Tsubuki… - Molecular …, 2022 - nature.com
… in our AD mouse model. Our findings provide a mechanism … disease characterized by the
deposition of amyloid β peptide (… diazoxide (Dz), a well-known K ATP channel activator with a …
deposition of amyloid β peptide (… diazoxide (Dz), a well-known K ATP channel activator with a …