Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model
F Brandes, K Schmidt, C Wagner, J Redekopf… - BMC cancer, 2015 - Springer
… were stimulated with hepatocyte growth factor (HGF). … invasiveness, motility and resistance
to gemcitabine therapy [12,… in MiaPaCa2(G250) cells under hypoxic conditions. This is of …
to gemcitabine therapy [12,… in MiaPaCa2(G250) cells under hypoxic conditions. This is of …
Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma
N Sperb, M Tsesmelis, T Wirth - International journal of molecular …, 2020 - mdpi.com
… into myofibroblasts through the accumulation of the hypoxia-… and invasiveness of primary
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …
Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
… (PC) by secreting hepatocyte growth factor (HGF). The … modulate proliferation, invasion
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …
Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility
M Sada, K Ohuchida, K Horioka, T Okumura… - Cancer letters, 2016 - Elsevier
… , migration, and invasion of cancer cells. Moreover, ECM in … interactions with cells that are
required for key cellular events… alignment in the tumor stromal [46] because a growing body of …
required for key cellular events… alignment in the tumor stromal [46] because a growing body of …
Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
O Hashimoto, K Shimizu, S Semba, S Chiba, Y Ku… - Pathobiology, 2011 - karger.com
… K, Koga Y, Miyazaki K: Tumor-stromal cell interaction under hypoxia increases the
invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int J …
invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int J …
[HTML][HTML] Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma
Q Wu, Y Tian, J Zhang, H Zhang, F Gu, Y Lu, S Zou… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… -derived factor-1, hepatocyte growth factor and galectin-1. … , plays a crucial role in tumor–stromal
interactions [82]. In … inhibited the invasion and metastasis of pancreatic cancer cells both …
interactions [82]. In … inhibited the invasion and metastasis of pancreatic cancer cells both …
HGF/c-MET axis in tumor microenvironment and metastasis formation
A Spina, V De Pasquale, G Cerulo, P Cocchiaro… - Biomedicines, 2015 - mdpi.com
… , Hepatocyte Growth Factor (HGF) is released by many cell … role in tumor stromal-interactions
under hypoxia [71,72,73]. … also the c-MET expression in pancreatic cancer cells PK8 [76]. …
under hypoxia [71,72,73]. … also the c-MET expression in pancreatic cancer cells PK8 [76]. …
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance
M Erkan, C Reiser-Erkan, CW Michalski… - Current molecular …, 2012 - ingentaconnect.com
… fibrotic/hypoxic milieu of pancreatic cancer through abnormal … dramatic rearrangement of
tumor-stromal interactions. It has … hepatocyte growth factor—in pancreatic stromal cells causes …
tumor-stromal interactions. It has … hepatocyte growth factor—in pancreatic stromal cells causes …
Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression
SP Pothula, RC Pirola, JS Wilson, MV Apte - Pancreatology, 2020 - Elsevier
… of organotypic pancreatic tissue cultured under hypoxic … facilitate the invasion and co-migration
of cancer cells through the … PSCs secrete the precursor form of hepatocyte growth factor (…
of cancer cells through the … PSCs secrete the precursor form of hepatocyte growth factor (…
Stromal biology and therapy in pancreatic cancer
… . Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic
cancer cells through the hepatocyte growth factor/c-Met pathway. Int J …
cancer cells through the hepatocyte growth factor/c-Met pathway. Int J …