XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

A Deczkowska, E David, P Ramadori, D Pfister… - Nature medicine, 2021 - nature.com
XCR1+ type 1 conventional dendritic cells drive liverXCR1 + type 1 conventional
dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
… of dendritic cells (DCs), including conventional and … Dendritic cells (DCs) and, in particular,
type 1 conventional … During NASH, inflammatory cues drive the hepatic recruitment of blood …

… liver contains distinct interconnected networks of CX3CR1+ macrophages, XCR1+ type 1 and CD301a+ type 2 conventional dendritic cells embedded within portal …

K English, SY Tan, R Kwan, LE Holz… - … and Cell Biology, 2022 - Wiley Online Library
… in large volumes of liver tissue from Cx3cr1 +/gfp , Xcr1 +/Venus , … toward liver pathology in
a mouse model of non-alcoholicXCR1 + cDC1s play important roles in priming and driving

Natural killer cells and type 1 innate lymphoid cells are new actors in non-alcoholic fatty liver disease

C Luci, E Vieira, T Perchet, P Gual, R Golub - Frontiers in Immunology, 2019 - frontiersin.org
… (fatty liver) to steatohepatitis (Non-alcoholic Steato-Hepatitis, NASH… that conventional liver
resident XCR1 + dendritic cells produce IL-… of innate immune cells (group 1 ILC, dendritic cells, …

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression

A Guillot, M Winkler, MS Afonso, A Aggarwal… - Hepatology, 2023 - journals.lww.com
… dramatic and quantifiable changes in liver histology. Chronic … , as well as conventional
dendritic cell scores in NASH and … cell population markers, such as MPO (neutrophils) or XCR1

Targeting immune cell-mediated features of non-alcoholic steatohepatitis

HMB Carvalho - 2023 - repositorio.ul.pt
… lipid acquisition and drives excessive liver fat accumulation … specialised macrophages (BMDMs)
or dendritic cells (DCs) (36)… XC Motif Chemokine Receptor 1 (XCR1)+ cDC1s. In the …

[PDF][PDF] T cells: friends and foes in NASH pathogenesis and hepatocarcinogenesis

P Ramadori, S Kam, M Heikenwalder - Hepatology, 2022 - Wiley Online Library
… Ibα; TG, triglyceride XCR1, XC chemokine receptor 1Dendritic cell populations with different
concentrations of lipid … migrate to liver and contribute to nonalcoholic fatty liver disease. …

The immune response as a therapeutic target in non-alcoholic fatty liver disease

N Ortiz-Lopez, C Fuenzalida, MS Dufeu… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a liver disorder … several immune cells, such as
macrophages, dendritic cells (… microbial factors drive the pathogenic function of B cells during …

Emerging roles of T cells in the pathogenesis of nonalcoholic steatohepatitis and hepatocellular carcinoma

P Hirsova, AO Bamidele, H Wang, D Povero… - Frontiers in …, 2021 - frontiersin.org
… of obesity and type 2 diabetes worldwide is driving a … macrophages, the liver contains a
population of dendritic cells (DCs) … In contrast, recent single-cell analysis has revealed that type 1

[HTML][HTML] Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis

AL Müller, C Casar, M Preti, D Krzikalla, C Gottwick… - Journal of …, 2022 - Elsevier
… Both innate and adaptive immune cells seem to contribute to cholangitis and drive PSC …
type 1 conventional DCs (cDC1s) as drivers of liver pathology in non-alcoholic steatohepatitis, …