2-Aminomethylphenylamine as a novel scaffold for factor Xa inhibitor
A Mochizuki, T Nagata, H Kanno, M Suzuki… - Bioorganic & medicinal …, 2011 - Elsevier
A Mochizuki, T Nagata, H Kanno, M Suzuki, T Ohta
Bioorganic & medicinal chemistry, 2011•ElsevierWe have been researching orally active factor Xa inhibitor for a long time. We explored the
new diamine linker using effective ligands to obtain a new attractive original scaffold 2-
aminomethylphenylamine derivative. Compound 1D showed very strong in vitro and in vivo
factor Xa inhibitory activity, as well as favorable PK profiles in po administration to monkeys.
new diamine linker using effective ligands to obtain a new attractive original scaffold 2-
aminomethylphenylamine derivative. Compound 1D showed very strong in vitro and in vivo
factor Xa inhibitory activity, as well as favorable PK profiles in po administration to monkeys.
We have been researching orally active factor Xa inhibitor for a long time. We explored the new diamine linker using effective ligands to obtain a new attractive original scaffold 2-aminomethylphenylamine derivative. Compound 1D showed very strong in vitro and in vivo factor Xa inhibitory activity, as well as favorable PK profiles in po administration to monkeys.
Elsevier
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