Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease

KR Rarick, K Li, RJ Teng, X Jing, DP Martin… - Free Radical Biology …, 2024 - Elsevier
… of SS mice, but not RAC, to levels observed in AA mice, we … to increase MLI but not RAC.
Exactly what such differential … and pulmonary intracellular ·NO bioavailability, resulting in …

[图书][B] The effects of estrogen treatment on lipid bioavailability and glycogen sparing in muscle during a two hour submaximal treadmill run in male rats

GS Ellis - 1989 - search.proquest.com
… Ovariectomy in female rats leads to increased carcass fat content, decreased activity, … Normal
female rats, estrogen-replaced ovariectomized female rats, and estrogen-treated male rats

Enantioselective metabolism of quizalofop-ethyl in rat

Y Liang, P Wang, D Liu, Z Shen, H Liu, Z Jia, Z Zhou - Plos one, 2014 - journals.plos.org
… from untreated rats were spiked with rac-QE and rac-QA … intragastric and intravenous
administration of rac-QE, which indicted … Pharmacokinetic parameters and bioavailability of QA …

Study on Factors Limiting Intestinal Drug Absorption: Contribution of interplay between metabolism and efflux transport in intestinal epithelial cells, and intestinal …

유헌민 - 2017 - s-space.snu.ac.kr
… EC-18 (ie, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol), an … the determination of EC-18 in
rat and mouse plasma and to … in determining the oral bioavailability. The intestinal stability may …

Metabolism of acrylamide in humans and biomarkers of exposure to acrylamide

T Kocadağlı, V Gökmen - Acrylamide in food, 2024 - Elsevier
… Oral bioavailability can be simply defined as the … bioavailability in humans and considerably
in rodents. Orally administered acrylamide is known to be rapidly absorbed in both rodents

mTOR Inhibition Prolongs Survival and Has Beneficial Effects on Heart Function After Onset of Lamin A/C Gene Mutation Cardiomyopathy in Mice

W Wu, Q Jin, C Östlund, K Tanji, JY Shin… - Circulation: Heart …, 2024 - Am Heart Assoc
… In contrast, Lmna H222P/H222P mice develop a … /H222P mice also develop atrioventricular
conduction disease by 3 … H222P/H222P mice with orally bioavailable mTOR inhibitors after …

Toxicokinetics and metabolism of 3-monochloropropane 1, 2-diol dipalmitate in Sprague Dawley rats

G Huang, B Gao, J Xue, Z Cheng, X Sun… - Journal of agricultural …, 2018 - ACS Publications
… form of 3-MCPD had 86% bioavailability compared with free 3-MCPD in Wistar rats at a …
and the deuterated internal standard rac 1,2-Bis-palmitoyl-3-chloropropanediol-d 5 (3-MCPD d 5 …

Curcumin: a potential neuroprotective agent in Parkinson's disease

RB Mythri, MM Srinivas Bharath - Current pharmaceutical …, 2012 - ingentaconnect.com
… A study exploring the effect of race and age on the … solubilization and hence improved
bioavailability. In a recent … in 154% increase in bioavailability in rats while in humans it reached up …

Factors Affecting Pharmacokinetics of Edaravone after Oral Administration: Solubilization and Efflux Transport

형성우 - 2019 - s-space.snu.ac.kr
… that govern the oral bioavailability of this antioxidant in the rats regarding four major
aspects … (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol), in rat and mouse plasma by liquid-…

MicroRNA-199a-3p and MicroRNA-199a-5p take part to a redundant network of regulation of the NOS (NO Synthase)/NO pathway in the endothelium

V Joris, EL Gomez, L Menchi, I Lobysheva… - … , and vascular biology, 2018 - Am Heart Assoc
… Interestingly, tissue profiling analysis has revealed that miR-199a is highly expressed in rat
… -exposed cardiomyocytes actually lowered NO bioavailability in rat cardiac endothelial cells. …