Cellular and molecular biology of aging endothelial cells

AJ Donato, RG Morgan, AE Walker… - Journal of molecular and …, 2015 - Elsevier
… in nitric oxide bioavailability downstream of endothelial … lead to a reduction in NO bioavailability
and a pro-oxidant … arteries from young rodents and older rodents that have undergone …

Considerations and recommendations for assessment of plasma protein binding and drug–drug interactions for siRNA therapeutics

SC Humphreys, JA Davis, S Iqbal, A Kamel… - Nucleic acids …, 2022 - academic.oup.com
… daily every three weeks to > monthly weekly to monthly Absorption orally bioavailable, fast
absorption not orally bioavailable, … unlabeled and 3 H met ID in intact and BDC animals (rat) …

Discovery of SCH 900188: a potent hepatitis C virus NS5B polymerase inhibitor prodrug as a development candidate

KX Chen, S Venkatraman, GN Anilkumar… - ACS Medicinal …, 2014 - ACS Publications
… The oral bioavailability of carboxylic acid 11 in rats, dogs, … bioavailability of active metabolite
11 increased substantially to 2%, 29%, and 63%, respectively. The low bioavailability in rats

Expanding the therapeutic potential of statins by means of nanotechnology enabled drug delivery systems

B Romana, M Batger, CA Prestidge… - Current topics in …, 2014 - ingentaconnect.com
… achieved via statin inhibition of Rac and the following reduction … to crude simvastatin after
oral administration to rats [47]. … Intrinsic dissolution rate, solubility and oral bioavailability in rats

Discovery of the first α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist dependent upon transmembrane AMPA receptor regulatory …

KM Gardinier, DL Gernert, WJ Porter… - Journal of medicinal …, 2016 - ACS Publications
rat and human hepatocytes was performed. As shown in the chromatograms in Figure 3,
the primary metabolites in rat … 6–8, rat liver microsomal metabolism of 13 (rac and individual …

[HTML][HTML] Plant derived bioactive compounds and their potential to enhance adult neurogenesis

P Sasikumar, M Aswathy, PT Prem… - Phytomedicine …, 2022 - Elsevier
… dementia conditions have plagued the human race for ages. It is … in mice with CMS compared
to that of unstressed mice. Rg1 … in lipid emulsion to increase bioavailability). Cognitive tests …

Protective effects of 18β-glycyrrhetinic acid on neonatal rats with hyperoxia exposure

C Qing, L Ziyun, Y Xuefei, Z Xinyi, X Xindong… - Inflammation, 2022 - Springer
… However, distal lung histology in neonatal rats exposed … RAC value (P < 0.01; Fig. 2). The
hyperoxia-exposed and 18β-GA-treated rats had increased alveolarization and a higher RAC

Enantioselective determination of mexiletine and its metabolites p‐hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal‐phase liquid …

ALPC Godoy, CC Parisi, MP Marques… - Chirality: The …, 2009 - Wiley Online Library
… -μl drug-free rat plasma samples spiked with 25 μl of each standard rac-MEX or metabolite
… no data regarding the bioavailability of individual enantiomers of MEX administered to rats. …

[HTML][HTML] Health benefits of astaxanthin and its encapsulation for improving bioavailability: A review

B Li, JY Lee, Y Luo - Journal of Agriculture and Food Research, 2023 - Elsevier
rats and mice, a beadlet preparation with 8% ASTX was not carcinogenic [68,69]. Another
study reported that dietary exposure of rats … another study treating rats with synthetic (3S, 3′S)-…

Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties …

D Babadi, S Dadashzadeh, M Osouli… - Journal of controlled …, 2020 - Elsevier
… [3]. However, in the past decades, various approaches to improve oral bioavailability of low
… Higher transport on the rat ileum in comparison to Caco-2 cells suggested the significant …