A general synthesis of ynones from aldehydes via oxidative C–C bond cleavage under aerobic conditions
We describe a direct synthesis of various ynones from readily available aldehydes and
hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work
synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the
desired ynone through an in situ C–C bond oxidative cleavage using molecular oxygen.
hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work
synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the
desired ynone through an in situ C–C bond oxidative cleavage using molecular oxygen.
We describe a direct synthesis of various ynones from readily available aldehydes and hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the desired ynone through an in situ C–C bond oxidative cleavage using molecular oxygen.
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