A highly-sulfated chondroitin sulfate, CS-E, adsorbs specifically to neurons with nuclear condensation
K Nakanishi, M Ito, Y Sato, A Oohira - Neuroscience Research, 2012 - Elsevier
A highly sulfated chondroitin sulfate, CS-E, prevents excitatory amino acid-induced neuronal
cell death by an as yet unknown mechanism. To reveal this mechanism, we pretreated
neurons in culture with various inhibitors, and examined whether N-methyl-d-aspartic acid
(NMDA)-induced neuronal cell death was reduced in the presence of CS-E. The inhibitors of
protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase II (CaMKII)
ameliorated NMDA-induced neuronal cell death, but did not affect the neuroprotective …
cell death by an as yet unknown mechanism. To reveal this mechanism, we pretreated
neurons in culture with various inhibitors, and examined whether N-methyl-d-aspartic acid
(NMDA)-induced neuronal cell death was reduced in the presence of CS-E. The inhibitors of
protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase II (CaMKII)
ameliorated NMDA-induced neuronal cell death, but did not affect the neuroprotective …
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