A myriad of pathways to NASH

S Larrain, ME Rinella - Clinics in liver disease, 2012 - Elsevier
… to the NASH population, we should consider what the appropriate therapy is for each
specific patient with NASH. The most effective pharmacologic treatments for NASH to date have …

Multi-drug approaches to NASH: what's in the development pipeline?

MP Johnston, J Patel, CD Byrne - Expert Opinion on Investigational …, 2020 - Taylor & Francis
… there is a myriad of agents … NASH will become analogous to the treatment of hypertension;
it is very likely that multiple different classes of drugs targeting different mechanistic pathways

Maladaptive regeneration—the reawakening of developmental pathways in NASH and fibrosis

C Zhu, I Tabas, RF Schwabe, UB Pajvani - … Reviews Gastroenterology & …, 2021 - nature.com
pathways and review the cell-autonomous and cell-non-autonomous mechanisms by which
developmental pathways … therapeutic implications of these data for NASH and liver fibrosis. …

[HTML][HTML] Recent insights into the multiple pathways driving non-alcoholic steatohepatitis-derived hepatocellular carcinoma

K Takakura, T Oikawa, M Nakano, C Saeki… - Frontiers in …, 2019 - frontiersin.org
myriad landmark discoveries of recent research into the pathogenic processes underlying
NASH-… related molecules in the inflammatory pathways underlying NASH-HCC progression, …

[HTML][HTML] Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation

W Peverill, LW Powell, R Skoien - International journal of molecular …, 2014 - mdpi.com
… but potentially multiple fibrogenic pathways exist in NASH, with … of NASH are aimed at the
myriad of inter-cellular mechanisms that have been implicated in the pathogenesis of NASH. …

Pharmacotherapy for NASH: current and emerging

MA Konerman, JC Jones, SA Harrison - Journal of hepatology, 2018 - Elsevier
… NAFLD and NASH are complex and reflected by the myriad of … In NASH, the developmental
pathway for therapeutic agents … as paediatric drug development pathways differ significantly. …

Clinical care pathway for the risk stratification and management of patients with nonalcoholic fatty liver disease

F Kanwal, JH Shubrook, LA Adams, K Pfotenhauer… - Gastroenterology, 2021 - Elsevier
… often inconsistent care processes characterizing current approaches to NAFLD/NASH. The
NAFLD/NASH Clinical Care Pathway presented in this article was assembled by an expert …

Innate immunity and inflammation in NAFLD/NASH

M Arrese, D Cabrera, AM Kalergis… - Digestive diseases and …, 2016 - Springer
… in NASH and the predominant cell death pathway in this disease [12, 22]. Apoptosis is initiated
by either membrane receptors (extrinsic pathway… consisting of a myriad of signals evoking …

[HTML][HTML] The cellular pathways of liver fibrosis in non-alcoholic steatohepatitis

N Méndez-Sánchez, A Valencia-Rodríguez… - Annals of …, 2020 - ncbi.nlm.nih.gov
… through the recognition of a myriad of danger signs known as … plays an important role in
NASH progression. Recent studies … In addition to these pathways, patients with NASH reveal …

[HTML][HTML] From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options

A Gastaldelli, K Cusi - JHEP reports, 2019 - Elsevier
… the impairment of many metabolic pathways, including decreased … for the treatment of NASH,
we discuss pharmacological … They also have a myriad of other beneficial metabolic effects, …