A novel approach for establishing benchmark CBCT/CT deformable image registrations in prostate cancer radiotherapy
Deformable image registration (DIR) is an integral component for adaptive radiation therapy.
However, accurate registration between daily cone-beam computed tomography (CBCT)
and treatment planning CT is challenging, due to significant daily variations in rectal and
bladder fillings as well as the increased noise levels in CBCT images. Another significant
challenge is the lack of'ground-truth'registrations in the clinical setting, which is necessary
for quantitative evaluation of various registration algorithms. The aim of this study is to …
However, accurate registration between daily cone-beam computed tomography (CBCT)
and treatment planning CT is challenging, due to significant daily variations in rectal and
bladder fillings as well as the increased noise levels in CBCT images. Another significant
challenge is the lack of'ground-truth'registrations in the clinical setting, which is necessary
for quantitative evaluation of various registration algorithms. The aim of this study is to …
A novel approach for establishing benchmark CBCT/CT deformable image registrations in prostate cancer radiation therapy
Results Inter-user variability of organ contouring on CBCT images was significant; the
overall mean DICE index was only 0.7 among physicians. Seminal vesicle volumes were
found to have the lowest correlation amongst physicians (DICE= 0.5). Mean DICE indices
based on DIR were 0.9 for prostate, rectum, and bladder, and 0.8 for seminal vesicles. Soft
tissue deformations were found to be smooth within the organs. Mean Jacobian values for
prostate, rectum, and seminal vesicles were in the range of 0.8-1.0, indicating mild …
overall mean DICE index was only 0.7 among physicians. Seminal vesicle volumes were
found to have the lowest correlation amongst physicians (DICE= 0.5). Mean DICE indices
based on DIR were 0.9 for prostate, rectum, and bladder, and 0.8 for seminal vesicles. Soft
tissue deformations were found to be smooth within the organs. Mean Jacobian values for
prostate, rectum, and seminal vesicles were in the range of 0.8-1.0, indicating mild …
