A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc (II) phthalocyanine and small molecule target-based anticancer …
FL Zhang, Q Huang, K Zheng, J Li, JY Liu… - Chemical …, 2013 - pubs.rsc.org
FL Zhang, Q Huang, K Zheng, J Li, JY Liu, JP Xue
Chemical Communications, 2013•pubs.rsc.orgIn this study, two phthalocyanine–erlotinib conjugates linked by an oligoethylene glycol
chain have been synthesised and fully characterised. Having erlotinib as the targeting
moiety, the two conjugates exhibited high specific affinity to HepG2 cancer cells and tumour
tissues, therefore leading to high photodynamic activity.
chain have been synthesised and fully characterised. Having erlotinib as the targeting
moiety, the two conjugates exhibited high specific affinity to HepG2 cancer cells and tumour
tissues, therefore leading to high photodynamic activity.
In this study, two phthalocyanine–erlotinib conjugates linked by an oligoethylene glycol chain have been synthesised and fully characterised. Having erlotinib as the targeting moiety, the two conjugates exhibited high specific affinity to HepG2 cancer cells and tumour tissues, therefore leading to high photodynamic activity.
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