A review on plant flavonoids as potential anticancer agents
Current Organic Chemistry, 2021•ingentaconnect.com
Flavonoids are polyphenolic compounds that are mainly derived from fruits and vegetables
and constitute an essential part of plant-derived beverages such as green tea, wine and
cocoa-based products. They have been shown to possess anticancer effects via different
mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of
apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of
multidrug resistance or a combination of any two or more of these mechanisms. The present …
and constitute an essential part of plant-derived beverages such as green tea, wine and
cocoa-based products. They have been shown to possess anticancer effects via different
mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of
apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of
multidrug resistance or a combination of any two or more of these mechanisms. The present …
Flavonoids are polyphenolic compounds that are mainly derived from fruits and vegetables and constitute an essential part of plant-derived beverages such as green tea, wine and cocoa-based products. They have been shown to possess anticancer effects via different mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of multidrug resistance or a combination of any two or more of these mechanisms. The present review summarizes the chemistry, biosynthesis and anticancer evaluation of flavonoids in both animal and human studies. A special emphasis has been placed on the flavonoids that are being screened in different phases of clinical trials for chemoprotective action against various cancers.
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