A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system
S Latini, M Pazzagli, G Pepeu, F Pedata - General Pharmacology: The …, 1996 - Elsevier
1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated
by the activation of the A 2 adenosine receptor subtype, have also been shown in the central
nervous system. 2. 2. Adenosine A 2a receptors are highly localized in the striatum, as
demonstrated by the binding assay of the A 2a selective agonist, CGS2680, and by analysis
of the A 2 receptor mRNA localization with in situ hybridization histochemistry. However …
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated
by the activation of the A 2 adenosine receptor subtype, have also been shown in the central
nervous system. 2. 2. Adenosine A 2a receptors are highly localized in the striatum, as
demonstrated by the binding assay of the A 2a selective agonist, CGS2680, and by analysis
of the A 2 receptor mRNA localization with in situ hybridization histochemistry. However …
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