[HTML][HTML] APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals–a cross …
LA Cysique, T Hewitt, J Croitoru-Lamoury, K Taddei… - BMC neurology, 2015 - Springer
Background Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a
characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated
neurocognitive disorder (HAND) remains unclear. Methods Adults with chronic treated HIV
disease were recruited (n= 43, aged 56.7±7.9; 32% aged 60+; median HIV duration 20
years,> 95% plasma and CSF HIV RNA< 50 cp/mL, on cART for a median 24 months). All
underwent standard neuropsychological testing (61% had HAND), APOE genotyping …
characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated
neurocognitive disorder (HAND) remains unclear. Methods Adults with chronic treated HIV
disease were recruited (n= 43, aged 56.7±7.9; 32% aged 60+; median HIV duration 20
years,> 95% plasma and CSF HIV RNA< 50 cp/mL, on cART for a median 24 months). All
underwent standard neuropsychological testing (61% had HAND), APOE genotyping …
APOE ε4 Moderates Abnormal CSF-abeta-42 levels, While Neurocognitive Impairment Is Associated With Abnormal CSF Tau Levels In HIV+ individuals-A Cross …
CA Lucette, T Hewitt, J Croitoru-Lamoury, K Taddei… - 2015 - ro.ecu.edu.au
Background: Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a
characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated
neurocognitive disorder (HAND) remains unclear. Methods: Adults with chronic treated HIV
disease were recruited (n= 43, aged 56.7±7.9; 32% aged 60+; median HIV duration 20
years,> 95% plasma and CSF HIV RNA/mL, on cART for a median 24 months). All
underwent standard neuropsychological testing (61% had HAND), APOE genotyping …
characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated
neurocognitive disorder (HAND) remains unclear. Methods: Adults with chronic treated HIV
disease were recruited (n= 43, aged 56.7±7.9; 32% aged 60+; median HIV duration 20
years,> 95% plasma and CSF HIV RNA/mL, on cART for a median 24 months). All
underwent standard neuropsychological testing (61% had HAND), APOE genotyping …
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