Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis
Y Wu, G Halverson, Z Basir, E Strawn, P Yan… - American journal of …, 2005 - Elsevier
OBJECTIVE: HOXA10, expressed in endometrium, plays an important role in uterine
receptivity at the time of implantation. In the endometrium of women with endometriosis, its
expression is reduced. The aim of this study was to determine whether the observed
aberrant expression of HOXA10 is caused by aberrant methylation of the gene. STUDY
DESIGN: Endometrial tissues were collected from 6 women with laparoscopically confirmed
endometriosis, and 4 women who underwent tubal ligation and were confirmed to have no …
receptivity at the time of implantation. In the endometrium of women with endometriosis, its
expression is reduced. The aim of this study was to determine whether the observed
aberrant expression of HOXA10 is caused by aberrant methylation of the gene. STUDY
DESIGN: Endometrial tissues were collected from 6 women with laparoscopically confirmed
endometriosis, and 4 women who underwent tubal ligation and were confirmed to have no …
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