Activating KIR genes are associated with ankylosing spondylitis in Asian populations
R Díaz-Peña, MA Blanco-Gelaz, B Suárez-Álvarez… - Human immunology, 2008 - Elsevier
Killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) loci are
both highly polymorphic. The aim of this study was to perform a KIR genotype analysis and
examine, in concert with HLA-B27 genotypes, their influence on ankylosing spondylitis (AS)
susceptibility in two Asian populations (one from China, 42 patients and 30 controls, and
another from Thailand, 30 patients and 16 controls). In the Chinese population, we observed
an increase of KIR3DS1, KIR2DS5, and KIR2DL5 gene frequencies in AS patients (pc< …
both highly polymorphic. The aim of this study was to perform a KIR genotype analysis and
examine, in concert with HLA-B27 genotypes, their influence on ankylosing spondylitis (AS)
susceptibility in two Asian populations (one from China, 42 patients and 30 controls, and
another from Thailand, 30 patients and 16 controls). In the Chinese population, we observed
an increase of KIR3DS1, KIR2DS5, and KIR2DL5 gene frequencies in AS patients (pc< …
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