Activation of astrocytes in the dorsomedial striatum facilitates transition from habitual to goal-directed reward-seeking behavior
Background Habitual reward-seeking behavior is a hallmark of addictive behavior. The role
of the dorsomedial striatum (DMS) in regulating goal-directed reward-seeking behavior has
been long appreciated. However, it remains unclear how the astrocytic activities in the DMS
differentially affect the behavioral shift. Methods To investigate the astrocytic activity-driven
neuronal synaptic events and behavioral consequences, we chemogenetically activated
astrocytes in the DMS using GFAP promoter–driven expression of hM3Dq, the excitatory …
of the dorsomedial striatum (DMS) in regulating goal-directed reward-seeking behavior has
been long appreciated. However, it remains unclear how the astrocytic activities in the DMS
differentially affect the behavioral shift. Methods To investigate the astrocytic activity-driven
neuronal synaptic events and behavioral consequences, we chemogenetically activated
astrocytes in the DMS using GFAP promoter–driven expression of hM3Dq, the excitatory …
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