Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice
M Ferron, N Merlet, T Mihalache-Avram… - Canadian Journal of …, 2023 - Elsevier
Background Polymorphisms in the adenylate cyclase 9 (ADCY9) gene influence the benefits
of the cholesteryl ester transfer protein (CETP) modulator dalcetrapib on cardiovascular
events after acute coronary syndrome. We hypothesized that Adcy9 inactivation could
improve cardiac function and remodelling following myocardial infarction (MI) in absence of
CETP activity. Methods Wild-type (WT) and Adcy9-inactivated (Adcy9 Gt/Gt) male mice,
transgenic or not for human CETP (tgCETP+/–), were subjected to MI by permanent left …
of the cholesteryl ester transfer protein (CETP) modulator dalcetrapib on cardiovascular
events after acute coronary syndrome. We hypothesized that Adcy9 inactivation could
improve cardiac function and remodelling following myocardial infarction (MI) in absence of
CETP activity. Methods Wild-type (WT) and Adcy9-inactivated (Adcy9 Gt/Gt) male mice,
transgenic or not for human CETP (tgCETP+/–), were subjected to MI by permanent left …
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