… model of spontaneous age-dependent cardiac fibrosis that develops … PAI-1 plays a significant
role in regulation of fibrosis by … -1 develop age-dependent cardiac fibrosis; the mechanism …

… and inhibition of anti-fibrotic signalling, leading to an … to age-related fibrotic cardiac
remodelling. In this review, we will discuss the fibrogenic contributors in age-related cardiac fibrosis, …

… regenerative capacity of the aged heart and lung … cardiac fibrosis and idiopathic pulmonary
fibrosis. This review focuses on these four processes of aging in relation to their role in fibrosis…

… In conclusion, the excessive fibrosis observed in the aged myocardium is determined by a
… stiffness increases in the aged myocardium as ventricular fibrosis progresses, as seen in the …

… targeting fibrotic remodelling, it may be necessary to consider age-… of the cardiac collagen
matrix as a function of age, whilst … role in limiting age-related cardiac fibrosis and development …

… -dependent cardiac fibrosis with age … aging model of both genders, the patterns of cardiac
fibrosis and CF phenotypes. This could lead to reconsider the management of cardiac fibrosis …

… Age-related changes in cardiac homeostasis can be observed at the cellular, extracellular, …
the gradual development of cardiac fibrosis are hallmarks of cardiac aging. In the absence of …

… (AMI) significantly attenuated post-AMI cardiac fibrosis. These 2 studies of CNP and its
potential role as an inhibitor of cardiac fibrosis are complemented by reports that CNP possesses …

Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of extracellular
matrix proteins, is a common pathophysiologic companion of many different myocardial …

… To help elucidate the mechanism of aging-related G-MDSC-mediated cardiac fibrosis, we
explored the phenotypes of cardiac fibroblasts in aging mice from the scRNA-Seq database (E-…