… To evaluate the impact of p53-mediated senescence on cardiac fibrosis, we compared
the … It is known that senescent cells accumulate with age in cardiovascular diseases and …

… cardiac specific deletion of STAT3 are significantly more susceptible to cardiac injury after
doxorubicin treatment than age-… a dramatic increase in cardiac fibrosis in aged mice. Although …

… Aging-associated fibrosis is characterized by increased … The age-related enhancement
of collagen crosslinking in the … in the pathogenesis of age-associated cardiac fibrosis [93]. …

… Tissue fibrosis is a hallmark of aging and is estimated to contribute to 45% of deaths in …
(v) The notion that mLOY causes cardiac fibrosis does not appear to be consistent with data …

… NEW & NOTEWORTHY The aging heart develops diastolic … function and reduction of cardiac
fibrosis was found only in the … the progression of the age-related interstitial cardiac fibrosis. …

… Experimental studies have demonstrated that age-related cardiac fibrosis plays an important
role in the pathogenesis of diastolic heart failure in senescent hearts. Reactive oxygen …

… aging, which may contribute to cardiac fibrosis. … cardiac fibrosis in an HSP70-dependent
manner, and that increase in cardiac fibrosis with aging may be partly attributable to the aging-…

… Notably, we clarified that aging-induced cardiac fibrosis primarily occurred … , and fibrosis in
aged rats was more severe (Fig. ​6). Exercise training decreased cardiac fibrosis in the aged …

… cardiac scars depending on the underlying cause of fibrosis. In this review, we present an
overview of what is known about cardiac fibrosis including the role of cardiac … in the aged heart…

… the finding that cardiac fibrosis and MBNL2 levels increase with age, we examined the effect
of MBNL2 gene silencing on the development of aging-related cardiac fibrosis. Aged rats (…