Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway
Y Ding, Y Wang, Y Zhang, B Dang, S Hu, C Zhao… - Phytomedicine, 2023 - Elsevier
Background Allergic rhinitis (AR) defined as inflammation and tissue remodeling of the nasal
mucosa in atopic individuals after allergen exposure. Alpha-linolenic acid [cis-9, cis-12, cis-
15-octadecatrienoic acid (18: 3)](ALA) as dietary supplementation can reduce inflammation
and allergic symptoms. Objective To evaluate the potential therapeutic effect and
mechanism of ALA in AR mouse model. Methods Ovalbumin sensitized AR mouse model
were challenged with oral ALA administration. Nasal symptoms, tissue pathology, immune …
mucosa in atopic individuals after allergen exposure. Alpha-linolenic acid [cis-9, cis-12, cis-
15-octadecatrienoic acid (18: 3)](ALA) as dietary supplementation can reduce inflammation
and allergic symptoms. Objective To evaluate the potential therapeutic effect and
mechanism of ALA in AR mouse model. Methods Ovalbumin sensitized AR mouse model
were challenged with oral ALA administration. Nasal symptoms, tissue pathology, immune …
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