Preclinical studies have suggested that opioid exposure may induce a paradoxical decrease
in the nociceptive threshold, commonly referred as opioid-induced hyperalgesia (OIH).
While OIH may have implications in acute and chronic pain management, its clinical features
remain unclear. Using an office-based quantitative sensory testing (QST) method, we
compared pain threshold, pain tolerance, and the degree of temporal summation of the
second pain in response to thermal stimulation among three groups of subjects: those with …