Abstract Fine particulate matter (PM2. 5), a major component among air pollutants,
highlights as a global health concern. Several epidemiological studies show the correlation
between chronical PM2. 5 exposure and incidents of neurological disorders including
Alzheimer's disease. However, the mechanisms have not been well understood, partly due
to the lack of model systems that reflect the physiologically relevant innate immunity in
human brains. Here, PM2. 5‐polluted human brain models (PMBs) are created in a 3D …

… Human Brain Model In article number 2101251 by Hansang Cho and co‐workers, PM2.5‐polluted
human brain models (PMBs) are created in a 3D microfluidic platform reconstituting key
aspects of human brain immunity under the PM2.5 exposure. The cover artwork shows the
potential risk of neuroinflammation on brain health induced by air pollutants from diesel
exhaust. Cover illustration by You Jung Kang. CT images of organs kindly provided by NIH. …