An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in …

L Gaohua, T Maekawa, H Kimura - Journal of Theoretical Biology, 2006 - Elsevier
Brain hypothermia treatment (BHT) is an intensive care characterized by simultaneous
managements of various vital signs, such as intracranial temperature (ICT) and pressure
(ICP), of the severe neuropatient. Medical treatments including therapeutic ambient cooling
and diuresis are separately carried out based on the experience of the medical staff involved
in the clinical management of various pathophysiological processes, such as
thermodynamics, hemodynamics and pharmacokinetics. However, no special attention has …
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