… of antifungal combination therapy to be conducted in two decades (166) and the rapid
proliferation of new in vitro and in vivo data on antifungal … is on the efficacy of antifungal drugs in …

… been studied in trials of empirical antifungal therapy for neutropenic fever. Only 1 trial has
studied what dose schedule is optimal for the treatment of documented infection. Ellis et al. …

… Also, we need to learn more about combination antifungal therapy, eg about the effects of
sequential blockade at two or more sites, and about the combination of antifungal agents with …

… by its very narrow antifungal spectrum activity. As … oral antifungal agents. The first landmarks
in the development of active and safe antifungal agents were the discovery of the antifungal …

… a continuing search for new therapeutic options. This search has … We are entering a new
era of antifungal therapy in which we … An early azole antifungal, ketoconazole, has been highly …

… The same is true for the application of antifungal pharmacokinetic/pharmacodynamic (PK/PD…
antifungal PK/PD predictions, and therapeutic monitoring may lead to optimized antifungal …

… of antifungal drug research has occurred because there is a critical need for new antifungal
… The overview of the development of antifungal therapy which is provided here demonstrates …

… an even greater role in antifungal therapy failure, such as host … antifungal therapy failure
in invasive mycoses, to help clinicians appreciate the meaning of primary antifungal therapy …

… antifungal agent issues, from the history of antifungal agents, fungal epidemiology, antifungal
… Second, we examine in depth the antifungal classes of drugs. Third, there is an attempt to …

… The availability of new antifungal agents with unique mechanisms of action and improved …
antifungal therapy for difficult-to-treat opportunistic mycoses. However, the use of this therapy …