Piper hispidum and Piper tuberculatum accumulate amides bearing isobutyl, pyrrolidine,
dihydropyridone and piperidine moieties. The isolation and characterization of several
representatives including two hitherto unreported amides were performed by
chromatographic techniques and by analysis of spectroscopic data. The antifungal activity of
each amide was determined by direct bioautography against Cladosporium
sphaerospermum.