Antihyperalgesic effect of exercise is augmented by the oral pretreatment with extract of Casearia sylvestris in an animal model of osteoarthritis
SD Pascoalino, DD Lüdtke… - Journal of …, 2020 - journals.sagepub.com
SD Pascoalino, DD Lüdtke, AC Heymanns, D Salm, DM Costa, DF Martins, VV Horewicz…
Journal of Orthopaedics, Trauma and Rehabilitation, 2020•journals.sagepub.comBackground/Purpose: Osteoarthritis (OA) is the main orthopedic disease to cause pain and
edema in humans. This study evaluated the influence of complementary medicine on the
hyperalgesia and edema induced by exercise in an animal model of OA as well as possible
role for interleukin (IL)-1β to these outcomes. Methods: Mice (25–35 g) were subjected to
intraplantar injection of Freund's complete adjuvant and were subjected to exercise and oral
treatment with ethanolic crude extract of Casearia sylvestris (ECE-CS) or vehicle (alone or in …
edema in humans. This study evaluated the influence of complementary medicine on the
hyperalgesia and edema induced by exercise in an animal model of OA as well as possible
role for interleukin (IL)-1β to these outcomes. Methods: Mice (25–35 g) were subjected to
intraplantar injection of Freund's complete adjuvant and were subjected to exercise and oral
treatment with ethanolic crude extract of Casearia sylvestris (ECE-CS) or vehicle (alone or in …
Background/Purpose
Osteoarthritis (OA) is the main orthopedic disease to cause pain and edema in humans. This study evaluated the influence of complementary medicine on the hyperalgesia and edema induced by exercise in an animal model of OA as well as possible role for interleukin (IL)-1β to these outcomes.
Methods
Mice (25–35 g) were subjected to intraplantar injection of Freund’s complete adjuvant and were subjected to exercise and oral treatment with ethanolic crude extract of Casearia sylvestris (ECE-CS) or vehicle (alone or in combination) and evaluated through behavioral and biochemical tests.
Results
At day 5, exercise and ECE-CS alone did not reduce hyperalgesia, while the combination of both enhanced this effect. In muscle and skin tissues from the treated paw of mice, both treatments alone or in combination reduced in similar extent the levels of IL-1β in relation to the control group.
Conclusion
Association of both complementary therapies may bring benefits on pain associated with OA in humans.
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