The focus of this chapter has been to describe and analyze prodrug approach using
quantum molecular orbital methods toward enhancing bioavailability of the antimalarial
agent, atovaquone, and to define design features to incorporate into prodrug approach to
accomplish that goal. Several medications, alone or in combination such as chloroquine,
antifolates, artemisinins and others show effectiveness and were considered as being the
corner stone in malaria treatment. However, drug or multi-drug resistance to these agents …