The effect of intraperitoneal administration for 28 days of 10, 20, and 30mg/kg body weight
per day of 20, 25-diazacholesterol dihydrochloride (SC 12937), a hypocholesterolemic
agent, on the testis of Parkes (P) strain mice was investigated. Histologically, testes in mice
treated with 10 or 20mg/kg body weight of SC 12937 showed non-uniform degenerative
changes in the seminiferous tubules as both affected and normal tubules were observed in
the same section; the affected tubules showed intraepithelial vacuolation, occurrence of …