Surface layer matrix-assisted laser desorption ionization mass spectrometry imaging (SL-
MALDI-MSI) is a powerful new surface sensitive imaging technique to establish surface
component localization of multicomponent polymer materials. This study demonstrates the
ability of SL-MALDI-MSI to image defects from foreign materials, material absence,
mechanical scribing, and solvent perturbation at the surface of low-molecular-weight poly
(methyl methacrylate) and polystyrene thin films. The surface specificity of the SL-MALDI …

Polymer thin films are often used in transdermal patches as a method of continuous drug
administration for patients with chronic illness. Understanding the drug segregation and
distribution within these films is important for monitoring proper drug release over time.
Surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging (SL-
MALDI-MSI) is a unique analytical technique that provides an optical representation of
chemical compositions that exist at the surface of polymeric materials. Solvent-free …