Association between cytokine gene polymorphisms and squamous cell lung cancer depending on the duration of smoking in men
LA Gordeeva, SA Mun, EN Voronina… - Ecological …, 2018 - journals.eco-vector.com
LA Gordeeva, SA Mun, EN Voronina, EG Polenok, AD Magatina, VA Titov, SE Ragozhina…
Ecological genetics, 2018•journals.eco-vector.comBackground. Squamous cell lung cancer (SCLC) is the most common form of lung cancer
among men smokers. Mediators and products of inflammation can contribute to the initiation
of carcinogenesis in smokers. The aim of study is to investigate the association between
IL1B (rs1143634, rs16944), IL1RN (rs2234663), TNFA (rs1800629), IL6 (rs1800795), IL10
(rs1800896) genes and SCLC depending on the duration of smoking in men. Materials and
methods. We studied 324 patients with SCLC and 168 healthy men smokers. The typing of …
among men smokers. Mediators and products of inflammation can contribute to the initiation
of carcinogenesis in smokers. The aim of study is to investigate the association between
IL1B (rs1143634, rs16944), IL1RN (rs2234663), TNFA (rs1800629), IL6 (rs1800795), IL10
(rs1800896) genes and SCLC depending on the duration of smoking in men. Materials and
methods. We studied 324 patients with SCLC and 168 healthy men smokers. The typing of …
Abstract
Background. Squamous cell lung cancer (SCLC) is the most common form of lung cancer among men smokers. Mediators and products of inflammation can contribute to the initiation of carcinogenesis in smokers. The aim of study is to investigate the association between IL1B (rs1143634, rs16944), IL1RN (rs2234663), TNFA (rs1800629), IL6 (rs1800795), IL10 (rs1800896) genes and SCLC depending on the duration of smoking in men.
Materials and methods. We studied 324 patients with SCLC and 168 healthy men smokers. The typing of the IL1RN (rs2234663) gene polymorphism has analyzed by polymerase chain reaction (PCR). Detection of the IL1B (rs1143634) and IL6 (rs1800795) polymorphisms have performed by restriction fragment length analysis, as a restriction enzyme TaqI was used. The IL1B (rs16944), TNFA (rs1800629) and IL10 (rs1800896) genes polymorphisms have determined through TaqMan-real-time PCR.
Results. The study showed, the age, duration of smoking and the number of cigarettes smoked per day were the main risk factors for SCLC in men (p< 0.0001). The IL6-174G allele was detected an additional risk factor of SCLC at a smoking duration of less than 35 years (OR= 1.68; 95% CI: 1.12-2.51; pcor= 0, 04). No association of IL1B (rs1143634, rs16944), IL1RN (rs2234663), TNFA (rs1800629), and IL10 (rs1800896) genes with the risk of SCLC in men was identified.
Conclusion. The duration of smoking and rs1800795 IL6 gene polymorphism may influence on the susceptibility to SCLC in men. Our results can be useful in understanding the molecular mechanisms of development of SCLC.
journals.eco-vector.com
以上显示的是最相近的搜索结果。 查看全部搜索结果