[PDF][PDF] Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor
H Yano, FS Lee, H Kong, JZ Chuang… - The Journal of …, 2001 - Soc Neuroscience
Nerve growth factor (NGF) initiates its trophic effects by longrange signaling through binding,
internalization, and transport of a ligand–receptor complex from the axon terminal to the cell
body. However, the mechanism by which retrograde transport of NGF takes place has not
been elucidated. Here we describe an interaction between the Trk receptor tyrosine kinase
and a 14 kDa light chain of cytoplasmic dynein. After transfection in human embryonic
kidney 293 cells, this 14 kDa dynein light chain was found to bind to TrkA, TrkB, and TrkC …
internalization, and transport of a ligand–receptor complex from the axon terminal to the cell
body. However, the mechanism by which retrograde transport of NGF takes place has not
been elucidated. Here we describe an interaction between the Trk receptor tyrosine kinase
and a 14 kDa light chain of cytoplasmic dynein. After transfection in human embryonic
kidney 293 cells, this 14 kDa dynein light chain was found to bind to TrkA, TrkB, and TrkC …
[PDF][PDF] Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor
JZ Chuang, JC Arevalo, P Pérez, CH Sung - 2001 - Citeseer
Nerve growth factor (NGF) initiates its trophic effects by longrange signaling through binding,
internalization, and transport of a ligand–receptor complex from the axon terminal to the cell
body. However, the mechanism by which retrograde transport of NGF takes place has not
been elucidated. Here we describe an interaction between the Trk receptor tyrosine kinase
and a 14 kDa light chain of cytoplasmic dynein. After transfection in human embryonic
kidney 293 cells, this 14 kDa dynein light chain was found to bind to TrkA, TrkB, and TrkC …
internalization, and transport of a ligand–receptor complex from the axon terminal to the cell
body. However, the mechanism by which retrograde transport of NGF takes place has not
been elucidated. Here we describe an interaction between the Trk receptor tyrosine kinase
and a 14 kDa light chain of cytoplasmic dynein. After transfection in human embryonic
kidney 293 cells, this 14 kDa dynein light chain was found to bind to TrkA, TrkB, and TrkC …