Background Roux-en-Y gastric bypass and biliopancreatic diversion can markedly
ameliorate diabetes in morbidly obese patients, often resulting in disease remission.
Prospective, randomized trials comparing these procedures with medical therapy for the
treatment of diabetes are needed. Methods In this single-center, nonblinded, randomized,
controlled trial, 60 patients between the ages of 30 and 60 years with a body-mass index
(BMI, the weight in kilograms divided by the square of the height in meters) of 35 or more, a …

The prevalence of type 2 diabetes and obesity is increasing to epidemic proportions
worldwide. Management of diabetes in obese patients presents particular and unique
challenges because oral hypoglycemic agents and insulin therapy can cause weight gain,
further exacerbating weight and metabolic control. Studies have reported that bariatric
surgery, either laparoscopic adjustable gastric banding or Roux-en-Y gastric bypass, can
improve type 2 diabetes and reduce rates of cardiovascular disease and death. This single …